BIOLOGY 1A03 Lecture Notes - Lecture 24: Germline Mutation, Dna Replication, Somatic Cell

• School: McMaster University
• Department: Biology
• Course: BIOLOGY 1A03
• Professor: Lovaye Kajiura

Document Summary

Errors in dna replication: can lead to changes at the nucleotide level, sometimes self-corrected, if not corrected, the incorrect nucleotide basses can be used as a template in the next round of replication,resulting the propagation of the mutation. Mutation is always a very rare event. There"s a variability as to the likelihood that a new mutation will occur at a given nucleotide bare pair in a single round of replication across different organisms. Most multicellular organisms have a relatively low probability of incurring a new mutation at a particular nucleotide pair in a given round dna replication. Viruses tend to have a much higher mutation rate. Cell mutations that are passed to progeny arise. T4m4 dna mutations from germline mutation since germ cells are cells that come together to produce new offspring in sexually reproducing organisms. Every cell in the developing embryo will carry the mutation.