Class Notes (1,100,000)
CA (620,000)
McMaster (50,000)
BIOLOGY (2,000)
Lecture 8

BIOLOGY 1A03 Lecture Notes - Lecture 8: Chromatin Remodeling, Cpg Site, Signal Transduction


Department
Biology
Course Code
BIOLOGY 1A03
Professor
Rosa Da Silva
Lecture
8

This preview shows half of the first page. to view the full 3 pages of the document.
Theme 3 Applied Lecture Epigenetics and Gene Regulation
Signals are detected by cells:
Environmental ques can change gene expression
Involves signal released from cell
Signal received by a cell
Receptors on target cell will bind the signal ex. Insulin receptors in liver and
muscles (liver stores and muscle uses) - released from pancreas
Signal transduction cascade can lead to short term or long term response
Short term: modify immediate cell processes ex. Metabolism and movement and can
include post translational modifications
Long term: modification of gene expression and development ex. Growth hormone
Levels of gene expression regulation:
1. Chromatin
2. Transcription
3. RNA processing
4. RNA stability
5. Translation
6. Post translational modification
Regulating gene expression at transcriptional level = epigenetic factors such as methyl
or acelty groups
DNA compaction regulates gene expression:
Epigenetic mechanism that allows unwinding or winding of DNA= methylation of
histone tails (relieves positive charge) or acetyl tails
Methylate CpG island is another epigenetic mechanism
Epigenome:
Modified genome modified by epigenetic modifications
Not changing DNA sequence only adding or modifying
Mechanisms include:
Modifications of histone tails
DNA methylation
Chromatin remodeling
Packaging of DNA around nucleosomes
You're Reading a Preview

Unlock to view full version