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Lecture 1

BIOLOGY 1A03 Lecture Notes - Lecture 1: Ribbon Diagram, Peptide, Monomer


Department
Biology
Course Code
BIOLOGY 1A03
Professor
Rosa Da Silva
Lecture
1

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Theme 1: The Structure of the Cell Module 3: Proteins
Unit 1: Proteins: What do they do, how are they made, what do they look
like?
Various functions
o
o
o
o
Various structures
o
o !"

o#$

How are protein structures represented?
o%&
Unit 2: Protein Synthesis: from DNA to Primary Protein Structure
Genetic information codes for proteins – same for prokaryotes and
eukaryotes
o&"!

o#'!&"
o'!&"
- Nuclear pores complexes
o&&"nucleolus
$ 


Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

o&

&"$


o&
free ribosomes
&bound
ribosomes 
(
(

o&"
All Proteins are Linear Polymers of
Amino Acids
-)*
-+$
$ 
$

-
polymers
polypeptides
- Primary sequence = ,
,
--&.
$($$

Translation Occurs Inside the Ribosome
- Condensation /
catalyzedribosome
-#-0.$
 

-,
&"$tRNA –
&"

Variable Side Chains Have Distinct Properties

Only pages 1-3 are available for preview. Some parts have been intentionally blurred.

-' 

- C-N bond = peptide bond
-1'$residues$
polypeptide
- Hydrophobic aggregate aqueous environment$

- Hydrophilic charge-polarized, ionic bonds,

-
23!

Free Ribosomes
Translate Proteins in the Cytosol
-&"$

-free ribosomes$
4$-
,.
- Remain in the cytosol- $'
-.
- Transported into nucleus- 
- Mitochondria or Chloroplasts-
Unit 3:Protein Folding
Properties of Macromolecules Determine
Structure
-
3

-3

-0!5$
 6
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The Linear Polymer is folded into a 3D Protein
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