BIOLOGY 1M03 Lecture Notes - Lecture 25: Cystic Fibrosis, Effective Population Size, Vicia Faba
10 Nov 2015
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Biology 1m03 - lecture 25 - human population genetics (continued) Effective population size is only the number giving birth to the new generation. Hemoglobin variants include blood groups, such as rh-negativity and rh- The origin of these mutations is much older than the origin of malaria so it didn"t evolve as a protection against malaria. Thalassemia is a mutation where two copies gives a disease, one mutation (heterozygosity) gives protection against malaria. Changes in metabolic enzymes can give rise to protection against malaria. Gp6d deficiency/favism (a digestive enzyme) is an x-linked gene. Males suffer more from this disease as a result. Agriculture arose around this time, and may be correlated with. Duffy antigens, a genetic system, protect against vivax malaria. this mutation. Cystic fibrosis is most common in europeans. There are about 4% carriers (1/2500 diseased: 2pq=0. 04, leading to q squared, which equals 0. 0004) This lung disease is lethal: involves mucus build-up.
