BIOLOGY 2A03 Lecture Notes - Lecture 1: Heart Failure, Comparative Physiology, Cardiac Muscle

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blackant529

19 Jan 2016

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Physiology: the study of how organisms work. One of biology"s most integrative disciplines (cells to whole animal performance) The goal: explain the physical and chemical factors for the origin and progression of life. How do they function and what are the mechanisms: study of mechanisms separates it from related. Various fields in science defined by their levels of fields focus organization: physiology integrates across many disciplines and levels of biological. Environmental physiology: how physiological systems respond and adapt to. Comparative physiology: various organisms mechanisms and changing environments evolutionary origins. Medical or pathophysiology: abnormal physiology as a result of disease. Pathophysiology: congestive heart failure due to insufficient o2 supply, impaired lung function eventually leads to death. Comparative physiology: how animals can live at altitudes of 5000 m with. O2 levels less than sea level vs northern elephant seal can breath-hold dive for over an hour. Tissues: collection of similar cells performing similar functions.

Related Questions

It's a quiz for my life science class.

QUESTION 1

Organisms that have descended from the same initial group and have the ability to interbreed belong to the same

	A.	species.
	B.	family.
	C.	class.
	D.	genus.
	E.	order.

5 points

QUESTION 2

The simplest entity that exhibits all of the properties of life is called a(n)

	A.	molecule.
	B.	cell.
	C.	organism.
	D.	tissue.

5 points

QUESTION 3

In populations, adaptation usually arises through

	A.	responsiveness.
	B.	heredity.
	C.	metabolism.
	D.	natural selection.
	E.	development.

5 points

QUESTION 4

Scientists have found that ancient fossils

	A.	are less similar to present-day organisms than more recent fossils.
	B.	are just as similar to present-day organisms as more recent fossils.
	C.	are more similar to present-day organisms than more recent fossils.
	D.	are very similar to present-day organisms.
	E.	bear no resemblance to present-day organisms.

5 points

QUESTION 5

What is the term that describes the study of the relationship between living things and components of their environment?

	A.	herpetology
	B.	analogy
	C.	zoology
	D.	ecology
	E.	ichnology

5 points

QUESTION 6

Characteristics usually associated with life include all of the following except:

	A.	motility.
	B.	a high degree of organization.
	C.	lack of change from generation to generation.
	D.	reproduction.
	E.	responsiveness to stimuli.

5 points

QUESTION 7

The scientific name for the black-footed ferret is Mustela nigripes. The name Mustela indicates the _____________________ to which the organisms belongs.

	A.	phylum
	B.	class
	C.	family
	D.	species
	E.	genus

5 points

QUESTION 8

Which of the following is considered to be the most basic living unit?

	A.	organ system
	B.	molecule
	C.	organelle
	D.	cell
	E.	tissue

5 points

QUESTION 9

Which of the following concepts best describes the wide variety of dog species we observe, ranging from the domesticated golden retriever or the basset hound, to the wild dogs of Africa, to foxes?

	A.	preadaptation
	B.	special creation
	C.	inheritance of acquired characteristics.
	D.	taxonomy
	E.	evolution

5 points

QUESTION 10

If an ecologist is studying the cycling of carbon through a particular environment (which involes the movement of carbon through living things as well as through rock, air, and water), the scientist is studying at what level of ecology?

	A.	organismal
	B.	community
	C.	ecosystem
	D.	population
	E.	biosphere

5 points

QUESTION 11

Which list is organized from smallest to largest level of organization of life?

	A.	organisms, organ systems, organs, tissues, cells, organelles
	B.	organelles, cells, tissues, organs, organ systems, organisms
	C.	organelles, tissues, cells, organ systems, organs, organisms
	D.	tissues, cells, organelles, organs, organ systems, organisms
	E.	cells, tissues, organ systems, organelles, organs, organisms

5 points

QUESTION 12

When examining the hierarchy of life, which of the following terms is most inclusive?

	A.	biosphere
	B.	population
	C.	species
	D.	ecosystem

5 points

QUESTION 13

The units of inheritance are

	A.	evolutions.
	B.	heredities.
	C.	genes
	D.	twins.
	E.	metabolic activities.

5 points

QUESTION 14

Organisms that undergo asexual reproduction

	A.	require another organism to reproduce.
	B.	are usually very complex.
	C.	produce offspring that are different from each other.
	D.	do not require energy to reproduce.
	E.	produce offspring that are identical to each other and to the parent.

5 points

QUESTION 15

All the living organisms in a particular area at a particular time make up a

	A.	biosphere.
	B.	community.
	C.	biosystem.
	D.	population.
	E.	ecosystem.

5 points

QUESTION 16

The first step in the scientific method is to

	A.	identify a problem.
	B.	predict the results of an experiment.
	C.	propose a solution.
	D.	draw a conclusion.
	E.	perform an experiment.

5 points

QUESTION 17

Young multicelled organisms usually start out small, then grow in size, and increase in complexity. This process is called:

	A.	heredity.
	B.	metabolism.
	C.	development.
	D.	evolution.
	E.	heredity.

5 points

QUESTION 18

To maintain order within their cells and organs, all living things must

	A.	carry on metabolism.
	B.	reproduce.
	C.	constantly change.
	D.	be able to move.
	E.	extract energy from sunlight.

5 points

QUESTION 19

Which of the following includes Highest levels of hierarchy?

	A.	family
	B.	phylum
	C.	domain
	D.	kingdom
	E.	order

5 points

QUESTION 20

Fungi are classified into which domain?

	A.	Archaea
	B.	Eukarya
	C.	Bacteria
	D.	Fungi

erinhare264

Please answer the question after reading the paragraph.

We have a global health challenge in our hands today, and that is that the way we currently discover and develop new drugs is too costly, takes far too long, and it fails more often than it succeeds. It really just isn't working, and that means that patients that badly need new therapies are not getting them, and diseases are going untreated. We seem to be spending more and more money. So for every billion dollars we spend in R&D, we're getting less drugs approved into the market. More money, less drugs. Now we have a whole pipeline of different organ chips that we are currently working on in our labs. Now, the true power of this technology, however, really comes from the fact that we can fluidically link them. There's fluid flowing across these cells, so we can begin to interconnect multiple different chips together to form what we call a virtual human on a chip. Now we're really getting excited.We're not going to ever recreate a whole human in these chips, but what our goal is is to be able to recreate sufficient functionality so that we can make better predictions of what's going to happen in humans. For example, now we can begin to explore what happens when we put a drug like an aerosol drug. Those of you like me who have asthma, when you take your inhaler, we can explore how that drug comes into your lungs, how it enters the body, how it might affect, say, your heart. Does it change the beating of your heart? Does it have a toxicity? Does it get cleared by the liver? Is it metabolized in the liver? Is it excreted in your kidneys? We can begin to study the dynamic response of the body to a drug. Organs on chips could also change the way we do clinical trials in the future. Right now, the average participant in a clinical trial is that: average. Tends to be middle aged, tends to be female. You won't find many clinical trials in which children are involved, yet every day, we give children medications, and the only safety data we have on that drug is one that we obtained from adults. Children are not adults. They may not respond in the same way adults do. There are other things like genetic differences in populations that may lead to at-risk populations that are at risk of having an adverse drug reaction. Now imagine if we could take cells from all those different populations, put them on chips, and create populations on a chip. This could really change the way we do clinical trials. And this is the team and the people that are doing this. We have engineers, we have cell biologists, we have clinicians, all working together. We're really seeing something quite incredible at the Wyss Institute. It's really a convergence of disciplines, where biology is influencing the way we design, the way we engineer, the way we build. It's pretty exciting.

Question: For years, technology and medicine have joined together to pave the way or even solve some of the worldâs greatest issues in healthcare. These issues include but are not limited to incurable diseases and disorders like AIDS and cancer. According to Geraldine Hamilton however, we as a population are spending too much money to develop drugs and solutions to these issues, only to be at a deficit with the drugs actually produced. She believes that one of the keys is how we test these drugs and finding more efficient ways to do so. As a result, she suggests the use of organs on chips, an innovation created and pioneered by her lab. The use of organs on chips could change the way new drugs are released and tested, thus possibly furthering the process of creating solutions to healthcareâs problems. Where is the fine line between technology and human innovation? Is human innovation gradually becoming depending on technology? (At least two paragraphs, a paragraph is at least 5 sentences long.)

Class 6: Viruses (and Cells, continued)

Making connections: viruses and microbes Match the cell biology concept (on page 1) with an important application of that concept (on page 2). Then answer the follow-up questions at the bottom of page 2.

Cell Biology concepts
1. Bacteria that cannot construct new cell wall material become fragile and break down.
2. During influenza infection, the viral enzyme neuraminidase is required to release new viruses from the host cell in which they were made. Once released, the new viruses can infect many additional cells.
3. Thermus aquaticus is a bacterium found in hot springs and can live at temperatures up to ~80Â°C (175Â°F). It has adapted so that its enzymes are most functional at the elevated temperatures, compared with many organismsâ enzymes that function best ~37Â°C (98Â°F).
4. Until the isolation and investigation of retroviruses, scientists thought that RNA could be copied from DNA, but DNA could not be copied from RNA. Research on this class of viruses led to an update to this âCentral Dogmaâ of biology.
5. Some bacteria have adapted, so that the enzymes involved in making cell wall materials have a slightly different shape and can no longer be bound by certain drugs.
6. Rhizobia are bacteria that colonize the roots of certain plants (legumes, including beans and peas). The host plant benefits from the prokaryotesâ ability to âfixâ nitrogen, converting N2 from the atmosphere into a form that is usable by the plant.
7. Many species of bacteria contain the enzyme cellulase. More than 10 billion such bacteria and other symbiotic microbes may be found in a single milliliter of material from inside the digestive system of ruminant mammals.
8. Fungi, including those that cause athleteâs foot, use ergosterol to maintain healthy membranes. Animal cells do not make ergosterol, they use a similar lipid â cholesterol.
9. During retrovirus infection, a DNA copy is made of the virusâs RNA genome. A cut is made in the host cellâs DNA and the DNA copy of the viral genome is pasted into the host chromosome by a viral enzyme called integrase.
10. Prokaryotic cells contain smaller ribosomes (â70Sâ ribosomes) than eukaryotic cells (â80Sâ ribosomes). Both types of ribosomes synthesize proteins, but the macromolecules they use to do it are somewhat different.

2
Applications
_______ Oseltamivir, also called Tamiflu, binds and inhibits the viral protein neuraminidase.
_______ Clotrimazole is a drug that is used to treat certain infections. It interferes with synthesis of ergosterol, a lipid involved in phospholipid membranes.
_______ Penicillin is a drug that interferes with synthesis of peptidoglycans (these are biological molecules that are part protein and part carbohydrate) that are present in certain cell walls.
_______ HIV is often treated with several drugs that inhibit different parts of the viral replicative cycle. Raltegravir is an example of a drug that interferes with the integration of viral genes into the host cellâs chromosome.
_______ Cows, like other vertebrates, lack the ability to breakdown cellulose. Yet they are able to live on a diet of grass and other vegetation high in cellulose.
_______ Enzymes isolated from extremophiles have been very useful in laboratory research. For example, Taq polymerase facilitates PCR, a revolutionary technique for production of DNAs of particular sequences, which requires cycling reactions through high temperatures.
_______ Plants and animals require nitrogen to make biological macromolecules, however theyâre unable to convert atmospheric nitrogen (N2) into a biologically useful form.
_______ Azithromycin is a drug that binds to 70S ribosomes and blocks synthesis of any new proteins.
_______ Methicillin-Resistant Staphylococcus aureus (MRSA) can cause life-threatening infections of the skin and bloodstream. One of the reasons MRSA infections are so serious is that they are resistant to treatment by many antibiotics, including methicillin and penicillin.
_______ The enzyme reverse transcriptase, isolated from retroviruses, is an important tool in molecular biology research. Scientists interested in learning what genes are turned on in particular cells use it to make DNA copies of RNAs they are studying (The DNA copies are useful because they are more stable).

When you have completed the matching activity, answer these follow-up questions:
â¢ What types of infections can be treated with the following drugs?
o Penicillin
o Clotrimazole
o Azithromycin
o Tamiflu
o Raltegravir
â¢ Why are these drugs (above) safe for you to take? That is, why donât they kill your cells?
â¢ Cancer cells are your own human cells that have become deregulated so that they divide and pile up in an uncontrolled way. Many chemotherapy drugs treat cancer by interfering with cell division and other cell processes.
o Why are there so many more side effects for individuals undergoing chemotherapy than for individuals taking antibiotics?

BIOLOGY 2A03 Lecture Notes - Lecture 1: Heart Failure, Comparative Physiology, Cardiac Muscle

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