BIOLOGY 2B03 Lecture Notes - Lecture 13: Transforming Growth Factor Beta, Signal Transduction, Targe
Document Summary
Can transform from unicellular amoeba into multicellular slug and then into a fruiting body through series of signals. Aggregated amoeba form the slug which can move towards heat, light, humidity in search of food. Aggregated amoeba occur during starvation because the starved cells release camp. camp: signal for aggregation of amoeba. G-protein coupled receptor (gpcr) is the camp receptor. Gpcr is a transmembrane protein, its extracellular domain binds specifically to camp gpcr is active cells reorganize actin network and move to source of camp signal aggregation occurs. The cell can move to the camp signal because the actin network reorganizes itself which forms a dynamic filopodia which extends out of the cell and allows it to move to the signal. If the slime mold has a mutated clatharin heavy chain, it will not be able to move proteins in vesicles from the golgi to the cell membrane, this includes the gpcr protein which is the receptor for camp.
