BIOLOGY 2B03 Lecture Notes - Lecture 11: Chromatin
11 Dec 2015
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Cell death is a normal part of life. # of cells in our body = equilibrium number apoptosis: too much or too little cell division = cancer. High rates of cell division development of multicellular organisms. Apoptosis is also important to many processes: webbing in hands and feet of human embryo 6 weeks, disappears by week 11 without apoptosis, webbing would persist. Tunel assay detects nicks in the dna of. Mouse paw stained with dye that labels cells undergoing apoptosis. Tunel assay: dna in apoptotic cells contains nicks or dna-breaks: bright green dots between developing digits, dutp incorporated into nicks by addition of an enzyme terminal deoxynucleotidyl transferase , allowing for detection of cells in apoptosis. Tadpole frog, cells in the tail are induced to undergo apoptosis: result: loss of tail. All changes during metamorphosis is stimulated by an increase in thyroid hormone in the blood. Similar process to tail loss in humans.
