BIOLOGY 3UU3 Lecture Notes - Lecture 5: Life Extension, Inbreeding, Insulin-Like Growth Factor 1
26 Sep 2016
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Document Summary
Growth negatively impacts the life span of mammals (rollo) Past mccay said growth and longevity are inverse in mammals, stunted growth of rats by restricting food which increased longevity. Transgenic gh mice or large size mice express reduce longevities, longevity enhanced in gh deficient dwarfs, mice with disrupted gh receptors, small size and mice transgenic for plasminogen activator (express reduced body mass and feeding rate) Taller humans, higher cancer rates, shorter lives. To longevity in mouse cohorts (selected on gr: but no appropriate global allometric analyses relating. Growth to life span in rats or mice. Variation sources: genders train genetic variation, group size, treatments, repo charac, nutrition, temp, humidity. Max longevity highly significant decline with increasing mature mass in rat and mice. W/respect to dr, growth retardation rejected as contributing to life extension because restricted adults (which reached mature size) also live longer: cell and prot.
