BIOLOGY 3UU3 Lecture Notes - Lecture 15: Hyperinsulinemia, Amylin, Hindbrain
12 Apr 2017
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Document Summary
The control of food intake: behavioral vs molecular perspectives. Satiation signals and adiposity signals on food intake: how they interact in the brain and how their influence changes with experience. Meal initiation is influenced by environmental factors. Meal size is influenced by an array of signals. Malleability of satiation signals renders them poor candidates as pharmacological targets to control body weight. Brain integrates information in hormonal and neural signals with data on energetic needs, anticipated needs, environmental factors, social situation, memory for past experiences, hedonic factors, etc. Normally fuel levels in the blood are relatively constant: use by tissues matched to secretion by liver and adipocytes. Meals causes spikes of glucose and other nutrients above basal levels, generating signals to the brain. Satiation signals during meals to limit meal size. Cck (duodenum) secreted in proportion to lipids and proteins in the meal: stimulates vagal axons hindbrain other brain areas. Hindbrain digestive reflexes influencing gi activity are initiated.
