BIOLOGY 3UU3 Lecture Notes - Lecture 14: Slow-Wave Sleep, Narcolepsy, Orexin
4 Apr 2016
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Salt exposure increases the acivity of immunological t cells upregulates them to transcend into a state of autoimmunity (ms) could exacerbate development of autoimmune diseases. In mouse model, there is a defect in a receptor that prevents degradaion of immunocytes, causing buildup, and they start responding to things that they shouldn"t. Anibodies being used as signals to atack (your own dna, receptors, anything picked up by immune system) Glutamate neuron excitotoxic poisoning of neurons around it loss of neurons. Cellular consituents get eaten by immune system autoimmunity. Sleep research what signals were regulaing sleep (some redox) Csf of goats when sleeping, inject into other goats causes goats to sleep (signal) One of the main parts of the signal turned out to be proteins from bacteria (not even made by body) Body was exposed to breakdown products of bacteria in gut lora caused sleep. Bacterial infecion, signals from infecive organisms will turn on sleep.
