BIOTECH 3PM3 Lecture Notes - Lecture 1: Inverse Agonist, Pharmacodynamics, Antihistamine
4 Dec 2017
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Mcmaster university biotech 3pm3 pharmacology week 01. Location where drug exerts: receptors are mostly proteins (95%) Mechanism of action: how does drug produce effects (mechanism of drug, non-molecular target drug (an-acid, laxative) Dose-response curve: drug proportional to dose, 99% of drugs have a target. Ligand binds to a receptor and then something happens. Re(cid:448)erses the effe(cid:272)ts of a (cid:862)(cid:272)onstituti(cid:448)ely(cid:863) a(cid:272)ti(cid:448)e re(cid:272)eptor. Already firing on its own without help from ligand, to stop this response you must use the inverse agonist. Need more drug when antagonist is present to get the same effect. Binding to a site other than active site. Maximum biological response is much less than full agonist but its does could be less, same or more. Conditions or symptoms for which a drug may be used. Situations or circumstance when a particular drug should not be used. Drug interaction refers to one drug affecting the actions of another drug. Metabolic: decreasing the concentration of the drug quicker.
