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Lecture 4

BIOTECH 4BM3 Lecture Notes - Lecture 4: Lead Compound, Drug Design, ParoxetinePremium

3 pages102 viewsWinter 2018

Department
Biotechnology
Course Code
BIOTECH 4BM3
Professor
Dr.R
Lecture
4

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BIOTECH 4BPM3 Biopharmaceuticals - Lecture 4
NMR vs X-ray Crystallography (advantages/disadvantage)
NMR
A-in solution (37 degree Celsius) can se the dynamic structure
D-need a huge amount of proteins (could assume different structures)
Crystallography
A-amazing picture resolution can see the smallest things in proteins
D- achieving the crystal is difficult
D- looking at crystal structure (solid state) might not reflect true dynamic nature
Traditional Pharmaceutical Drug Discovery
Plants
-25% of all drugs prescribed today were isolated from plants
Microbes
-Fungi
Plant Screening Methods
-Random collection and screening
-Works best in areas supporting a diversity of plant species
-Targeted screening of likely candidates
-Plants with resistance to disease or predation may be producing toxic substances likely ro have
some effect on human cells
-Ethnobotanical approach collection of plant specimens used as local cures by indigenous
communities
1-2 kg of plant materials is collected, dried crushed, and extracted with various solvents
-Solvents are removed/evaporated and the extracts are screened for desirable biological
activates
-If interesting activity we need more plant 15-20 kg (lead compound)
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