CHEM 2OB3 Lecture Notes - Lecture 6: Phosphorylase, Acetyl-Coa, Trigonal Bipyramidal Molecular Geometry
16 Sep 2014
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Wittig reagent (trivalent, tetrahedral) phosphorus pentachloride phosphate (pentavalent, trigonal bipyramidal) (pentavalent, tetrahedral) The biologically important forms of phosphorus are phosphates and phosphonates. R3 phosphonate (r1 = c; r2,r3 = c or h) There are significant similarities between phosphate chemistry and carboxylic acid derivatives. All the oxygens with a given protonation state in a structure are equivalent to each other. O- phosphoric acid monobasic phosphate dibasic phosphate tribasic phosphate. At physiological ph, phosphate is a mixture of the monobasic and dibasic forms. Phosphate monoesters are acidic and completely deprotonated under physiological conditions, with a charge of -2. Coo- glucose 6-phosphate (1st step of glycoysis) phosphoenolpyruvate (high energy phosphate) (pep) Phosphate diesters are acidic and completely deprotonated under physiological conditions, with a charge of -1. Phosphate triester do not appear to occur in nature, but they are important as neurotoxins, and pesticides. For example, paraoxon is an insecticide that blocks the action of the neurotransmitter acetylcholine by inhibiting acetylcholine esterase.
