HTHSCI 1DT3 Lecture 7: Variety of Antibodies
4 Mar 2016
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Document Summary
B-cells don"t have much cytoplasm usually, but once activated: grows largely so that can produce antibodies > become part of plasma. Heavy chain: b/c physically big, behave like a big molecule in centriguge. Light chain: doesn"t have like something bid in centrifuge. Need both heavy and light chain; 2 binding sites: capable of binding 2 antigens at the same time. Other end of molecule: communications end: communicates to immune system: have bound to antigen! Communication site opened through conformational change through binding of antigen, recognized by macrophage, etc. Main function: mark antigens for destruction (don"t kill anything direct, need complement system, other immune cells, etc. ) Prevent antigens from causing harm before they are destroyed, give immune system time to nd. Thursday, january 28, 2016 market target. (binding must happen, bind to parts of antigen that cause harm, Neutralize the antigen, physically getting in the way of the antigen: tetanus (lockjaw): causes muscle contraction, no relaxation, polio: from sewage, oral.
