HTHSCI 1DT3 Lecture Notes - Lecture 5: Melanoma, Natural Killer Cell, Interleukin
4 Mar 2016
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White blood cells and cancer : dr. jonathan. Take away blood cells from cancer patients, manipulate them to kill off cancer. White blood cells: fight infection, lymphocytes, monocytes: fight bacterial, virus, eosinophil. Normal cell: cells stop growing when reach certain limit > programmed by genes, some emerge as cancers: broken free of natural control, will eventually kill the host t-lymphocytes. When certain protein fragments are made available, t-lymphocytes recognize, program of destruction, destroy target cells, detrimental if unchecked! Tumour cells also display protein fragments that are different from normal cells. Knowledge of this biology > hypothesis: immune surveillance: tumors, abnormal cells constantly arising in body. 1: however, are recognized and cleared by the immune system. Corollary to the immune surveillance hypothesis: failure of immune system to clear malignant cells leads to tumour formation. As tumours grow, gain ability to evade immune control. Patients with many t-cells in tumours survive longer, despite treatment.
