HTHSCI 1DT3 Lecture Notes - Lecture 15: S100 Protein, Hmgb1, Anaphylaxis
15 Mar 2016
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Remember: no direct sensing (pamp-prr) of allergens by the immune system: alternative ways of sensing by the immune system (activities caused rather than entities themselves) Tissue damage mediated by alarmins or damps (damage-associated. Alarmins: s100 proteins, hmgb1, uric acid crystals, edn. Paul happens to be a nice, innocent, innocuous person but ends up getting arrested in a back alley: other bad guys in that place have primed the police for a specific perception (paul is guilty by association) Disturbances in the microenvironment may prime the immune system to react to otherwise innocuous antigens. Concept: allergen + alarmin leads to generation of immune response: nomenclature. Antigen: a substance, generally a protein, capable of triggering an immune response. This response includes the production of antibodies as well as the generation/activation of cells that will produce molecules aimed at killing/neutralizing the harmful intruder. Allergen: a substance, generally a protein, that triggers a type i-iv hypersensitivity reaction (allergic reaction)
