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Lecture 19

HTHSCI 1H06 Lecture 19: Tubular Function

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Health Sciences
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Peter Helli

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Tubular Function Tuesday, March 21, 2017 The Nephron Made up of renal corpuscle that makes filtrate Renal tubule and collecting duct that makes urine Afferent arteriole blood comes into glomerulus and goes out to the efferent arteriole Downstream we have the peritubular capillaries Blood at end goes out back into general circulation, not all of it but some, some is made into filtrate Most filtrate is reabsorbed Some special chemicals are secreted from blood to tubules (penicillin) Urine goes to ureters and then to the bladder What to do with 180 L of filtrate Some completely reabsorbed: wont see those in urine Some regulated and partially reabsorbed Some excreted as waste: pushed into filtrate or not going to be reabsorbed Much Depends on the renal tubules Renal corpuscle has glomerular capsule and glomerulus Next, proximal convoluted tubule which receives all the filtrate Goes down into the loop of Henle Descending limb of LOH is water permeable, can leave that limb Ascending limb is impermeable to water, but does allow solutes Distal convoluted tubule is where we begin the final preparation for getting rid of urine Final thing is going to happen in the collecting duct which is variably permeable to water In the renal cortex we find the distal and proximal tubule and renal corpuscle In the renal medulla we find the LOH and collecting duct Renal cortex is on outside and penetrates deeply as columns Renal medulla is pyramids, papilla leak urine Blood supply: coming in is arterial supply at arcuate artery, coming from arcuate we have the interlobular arteries which throw off the afferent arteriole, coming out is the efferent arteriole Blood that comes across the tubules have to be collected, blood goes across tubules and collected by veins Blood is going to be connected into arcuate vein Reabsorption of solutes and water Can occur by active transport or passively Movement of water is always by osmosis which is a passive mechanism High to low Movement of solutes form tubules into interstitial fluids drives osmosis 90 of water is pulled back into system, obligatory 10 of water is facultative, can increase or decrease depending on the amount required by body Obligatory occurs in proximal convoluted tubule and LOH, permeable to water all the time Facultative is under control of ADH, keeps you from urinating by making less of filtrate into urine and does so in collecting duct
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