HTHSCI 2FF3 Lecture Notes - Lecture 7: Immunoglobulin Light Chain, T Helper Cell, Co-Stimulation
1 Nov 2016
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Document Summary
To get to the adaptive immune system, the first 3 barriers of defence must have been breached: Innate immunity (resident immunity: early induced innate response (inflammation) Antigens can be any protein in a pathogen. Adaptive immunity(ai) memory: lag phase when ai is ramping up antibody generation. Antigen presenting cells (apcs) bridge both immune systems. If a b cell makes an antibody, this must be in response to an antigen: An antibody is a dimer that has 2 heave chains, and 2 light chains. Each antibody can bind at least 2 antigens that are not processed. B cells make antibodies which can bind to antigens whether they be processed or not. T cells can only bind to antigens that are processed and presented on mhcs, thus the need for apcs. Analogy: mhc is a billboard, the antigen processed is the text on the billboard. Note mhc is found in mice the equivalence in humans is.
