HTHSCI 2H03 Lecture Notes - Lecture 7: Aromatase, Misoprostol, Coronary Artery Disease
2 May 2016
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Secondary sexual characteristics (body hair, muscle growth etc depends on gender) Affect the ovaries and uterus in the menstrual cycle: there is negative feedback of the sex hormones to the pituitary and hypothalamus. Initially, estrogen has positive local control (feeds back on cells producing estrogen to increase the number of lh and fsh receptors) and negative central control (decreases the release of. Gnrh, lh and fsh, which prevents further growth of less developed follicles) The central positive feedback is switched back to central negative feedback, decreasing the levels of gnrh, lh and fsh. The corpus luteum stimulates the secretion of progesterone and estrogen. Increased estrogen and progesterone production promote endometrial vascularation and thickening. (note: the effects of progesterone dominate at the level of the uterus: onset of menstruation. As the corpus luteum degrades, estrogen and progesterone secretion is inhibited (also note that. Gnrh, lh and fsh levels have also dropped off).
