HTHSCI 2H03 Lecture Notes - Lecture 3: Anesthetic, Amide, Acid Dissociation Constant
24 May 2016
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Document Summary
Causes vasoconstrictive effect that prolongs duration of action by reducing bloodflow, and therefore the amount of drug that gets carried away and metabolized. Used when we are using esters or amides because they are weakly basic like absorbs like. Onset of action may be accelerated enhances intracellular access of weakly basic compounds. Local anesthesia administered around the site of the procedure to constrict these blood vessels and prolong the duration of action by preventing redistribution. Used when we want drug to be absorbed more quickly or holistically. Also used in spinal anesthesia, slow post operative epidural infusion at low concentrations successfully used for post operative analgesia. Short half life (1-2 minutes) used to be used for dental procedures, and patients would be anesthatized at the start, and then quickly begin to feel pain as procedure progressed. Anesthetics (cyp450) procedural when looking at local or local regional areas. * not metabolized by esterases provides better coverage for procedures.
