HTHSCI 2H03 Lecture Notes - Lecture 8: Drug Class, Thrombin, Anticoagulant
24 May 2016
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Document Summary
Lengthens clotting times and prevents thrombi form forming (or growing larger) in veins or arteries. Main agenda is to modulate coagulation cascade and thrombin formation. Lengthening of clotting times will prevent thrombi form forming in both veins and arteries. Iv or sc for rapid onset of action. Enhances the ability of antithrombin iii to inactivate thrombin and clotting factor xa. Thrombin no longer able to convert fibrinogen into fibrin. Inhibition of factor xa, inhibits intrinsic and extrinsic pathways of the clotting cascade. Dvt, pulmonary embolism, disseminated intravascular coagulation (dic) treatment of. Protamine sulphate binds to heparin and inactivates it. Can have variable response for heparin because it affects two components of coagulation cascade. Can have immune response see platelet count dropping. Blocks synthesis of clotting factors and thrombin, vlla, ixa and xa. Precursors require carboxylation to become active process very tightly controlled by vitamin k. Binds very strongly to proteins (age variability), therefore highly problematic.
