HTHSCI 2H03 Lecture Notes - Lecture 9: Nebulizer, Leukotriene, Asthma
Document Summary
Bind to beta-2 receptor in the lungs. Receptor associated with g- protein camp. Greater effect on organelle than histamine or leukotrienes overrides their effects. Calcium levels fall and we see relaxation. Promoting sympathetic division resulting in reduced calcium stores. Most effective and rapid acting bronchodilato r terminates attack. Few adverse effects associated with inhaled route of administration (dry mouth, sedation) * dry mouth is antiparasympathetic action not seen as much. Work by antagonizing muscarinic receptors in the smooth muscle of the bronchi. Commonly used in those with copd, chronic bronchitis. Work directly at the level of the transcription factor. Binds to a receptor receptor glucocorticoid complex and is taken into cell and binds to response elements. Low dose: throat irritation, oral candidiasis (destruction of normal flora at back of throat, thrush) Acts directly at the level of the. Inhibits phospholipase a2 shuts down arachadonic acid cascade inhibits all inflammatory products.