HTHSCI 2H03 Lecture Notes - Lecture 4: Thromboxane A2, Cytochrome C Oxidase Subunit Ii, Cyclooxygenase

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 2H03
• Professor: Kirsten Culver

Document Summary

Block the action of the cyclooxygenase enzyme. This reduces pain and fever (pgls that are pyretics) Prostaglandin synthesis all over the body will be affected because of their non-selective nature (both. Inhibits platelet aggregation (thromboxane a2 knocked out) Present at sites of tissue injury forms prostaglandin s when it gets access to arachadonic acid. Increased risk of fatal gastric bleeding and kidney failure (long term use) Asthmatics blocking cyclooxygenase shifts the arachadonic pathway towards the formation of. Patients with 1 kidney, kidney damage, or taking kidney meds its class. Those at high risk of mi and htn. High risk of stroke, mi and asymptomatic htn. ** only used in individuals who have established that they have a lower than average risk of mi and stroke. Used when inflammation cannot be managed with nsaids. * need to try to keep this therapy as localized as possible taking them orally means systemic effects.