HTHSCI 2H03 Lecture 6: LIPIDS-DRUG-CLASS
24 May 2016
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Document Summary
Inhibits activity of hmg-coa reductase blocking synthesis of cholesterol. Increases number of ldl receptors in the liver and stimulates the removal of ldl from the blood. Main driver to reducing cholesterol is drive to bring cholesterol from the peripheries. Increase density of ldl receptors which decreases ldl cholesterol in blood stream. * effects may take up to a month. Firstline therapy for treatment of lipid disorders. Effects are reversible benefits will stop once therapy is removed. Pregnancy cholesterol is vital to formation of hormones in pregnancy. ** associated with increased risk of new onset, t2 dm on antidiabetic drugs to prevent hyperglycemia. Gi upset take with an evening meal, this is when cholesterol intake is highest. Rhabdomyolysis risk with higher doses, or coadministration of drugs that inhibit cyp 450 enzymes. Potentiate effects of warfarin, increase estrogen levels in women using combination oral contraceptives.
