HTHSCI 2H03 Lecture Notes - Lecture 5: Norepinephrine, Short-Term Memory, Cerebral Cortex
24 May 2016
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Neurons originate from the locus ceruleus and project forward into limbic system and cerebral cortex. Indications (disease state) primary, secondary and tertiary. Maintains emotional tone (mood, arousal, wakefulness and reward) Sleep wake cycle is heavily influenced by this system. Capacity to experience reward is greatly affected. Decreased noradrenergic activity is associated with depression. Neurons originate in the raphe nuclei and project to the limbic system and cerebral cortex (colocalized with ne system) * caution: when you look at the negative symptoms of schizophrenia, they look a lot like depression, however they are decreased in different. * treat with antidepressants for both but in different ways for different reasons. bipolar. Maintains sleep- wake cycle, emotional tone and sensory perceptions (pain) Can boost serotonergic signal and mitigate pain response triptans and tcas. Regulate neurotransmitters in the brain by preventing reuptake, or inhibiting degradation. Treatment of major depression, bipolar affective disorders.
