HTHSCI 2H03 Lecture Notes - Lecture 4: Antipsychotic, 5-Ht2A Receptor, Autoreceptor
24 May 2016
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Document Summary
Drug is taken up by dopaminergic receptors in the brain. Agonize autoreceptors presynaptically, and antagonize them postsynaptically way too many post synaptically, because there is little activity presynaptically. Clients with schizophrenia have many 5-ht2a receptors, and by agonizing these, we restore these receptors releasing serotonin. Some also exhibit affinity for serotonin receptors . * we prefer this approach of atypical neuroleptics provides a more holistic view manages both. * we see an increase in serotonergic activity in schizophrenia because of increased density of autoreceptors post synaptically positive and negative symptoms. Not nearly as potent in antagonism as typical neuroleptics. Blockade of d2- like receptors, reduces hallucinations and delusions (not with as high an affinity as haldol) Ht2a and stimulation of 5-ht1a receptors reduces blunted affect, anhendonia, etc. Used in the treatment of psychotic disorders and affects both the positive and negative symptoms. What is currently seen in practice today. Effective in treating both the positive and.
