HTHSCI 3I03 Lecture 5: Innate Immunity II

• School: McMaster University
• Department: Health Sciences
• Course: HTHSCI 3I03
• Professor: Martin Stampfli

Document Summary

There are many innate immune cells and molecules under the epithelium of skin and mucosal surfaces. The innate immune cells and molecules have the ability to: encounter any invading pathogens, 1. To destroy and kill invading pathogens within seconds/min/hours: 2. To recognize them and induce an innate immune system: have receptors to recognize them, an that recognition will lead to an induced innate immune system. Bone marrow is the site of hematopoietic activity, after birth, in mammals. Platelets and erythrocytes: part of innate immune system, platelets and rbc are important in setting the stage for clotting, and trapping microbes at area of clotting. All 3 of them exist just under epithelial cells, very efficient: if pathogen enters they will track & kill. Bound material is internalized in phagosomes bnd broken down in phagolysosomes: process of acidification leads to release of cytotoxic materials in those granules.