HTHSCI 3I03 Lecture Notes - Lecture 5: Innate Immune System, Cytokine, Autocrine Signalling
12 Dec 2018
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Document Summary
If you have local infection or local tissue damage you release of lots of pamps and. Damps: the macrophage and apc will recognize them and then you have various strong induction of innate immunity, that signal pathway will lead to the release of cytokine or proteins, those protein will have local and systemic effects. If we have enough antigen and simulation at the site of local damage, then we wll start to produce a lot of cytokine by the local macrophages: each of the cytokines have different function. Cytokines (cyto-, cell; kinos- movement: small proteins (15-25 kda) released by various cells protein produced by any cells in the body, similar to hormones and can act in intracrine, autocrine, justacrine, paracrine, endocrine and exocrine manner. In the location of the infection, we have lots of blood cells those chemokines and cytokines have two jobs (happen in the first day: dilate the blood vessels nearby, bring lot of help to the site.
