HTHSCI 3I03 Lecture Notes - Lecture 4: Innate Immune System, Organ Transplantation, Pattern Recognition
12 Dec 2018
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Document Summary
Innate 3: pathogen recognition and induction of innate immunity. Immune system recognizes what is infectious: doesn"t explain pregnancy and tumor, danger hypothesis. Immune system over time adapt to recognize what is dangerous: recognition start with innate and end with adaptive. The innate immune system recognizes danger signals with very small amount of receptors: external dangers (pamps) Inside the cells all of which recognizes nucleic acid: out-side of the cell recognized lipids and protein, 2 main pathways between toll-like receptors and ligands (myd88 pathway and the other. Nlrs: *inflammation caused from soccer, nlr pathway in the end of the day leads to the production of il-1b and cleavage of il-18. Induction of innate immune system from adaptive system is not black and white it is a scale: adaptive is less sensitive, but very specific (opposite for innate, limited receptors in innate, but thousands of pathogens.
