HTHSCI 3I03 Lecture Notes - Lecture 12: T Helper Cell, Dendritic Cell, Cytokine
12 Dec 2018
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We have resting dendritic cells in the skin resting waiting for action and danger signals: when they perceive danger, they move to a draining lymphatic vessel. The t cells enter through the blood and interact. If they recognize the antigens, they colonial expand and develop effector function: dendritic cells enter through the lymphatics. T cells can also enter a lymph node from upstream lymph nodes or lymphatics vessels: when they come in they will find the dendritic cells displaying their antigens. Cytokines: signal 3, cyto = cell, kinos = movement, any small protein made by a cell tat affects the behaviour of other cells. Inter = between: leuk = leukocytes, a name for cytokine produced by leukocytes typically abbreviated as il, lfa -1 is in integrin which interact with icam-1. In resting t cells, there are no reaction between tcr and mhc nothing is phosphorylated internally: when interaction happens, itam motifs are phosphorylated by lck.
