HTHSCI 3K03 Lecture 1: HTHSCI 3K03 Lecture Notes Compiled
12 May 2017
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>4000 known: genome = dna/rna in cell, viruses cannot translate proteins ! must use host ribosomes/machinery, doesn"t do something new uses existing processes. Spontaneous assembly of newly synthesized components ! progeny virions: based on encoded instructions. Attachment: susceptible has receptor, permissive replication + progeny production. Protection from extracellular environment: release in proper compartment of cell, body has different epithelial surfaces, different surfaces/receptors, different proteins + lipids + carbs + salicylic acid, may be anchored to cytoskeleton. Tropism: virus tends to invade/replicate in cell type/tissue (may not be receptor related) Host range: species that are susceptible + permissive. Invaginates, pinches off ! vesicle: becomes acidified. Fuses with lysosome (causes ph change!!: virus uses ph change as signal, ha receptor on enveloped influenza binds to sialic acid. Release viral particle by riding on histones ! nuclear pore: poliovirus, rna virus ! cytoplasm. Assembly: must be protected until next host (cell/organism)
