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Class Notes for Integrated Science at McMaster University (page 3)

ISCI 1A24 Lecture Notes - Lecture 14: Social Learning Theory, Fishing Rod, Light Shift
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Influence of Others Module Life Science Norman Triplett:  Observed that cyclists raced faster when competing against each other in a group compared to against the clo...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 17: Cell Cycle Checkpoint, Spindle Apparatus, G1 Phase
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The Cell Cycle November 25, 2013 Slime Molds:  Phylogenetically anomalous – resemble fungi, moss, or even “dog barf” Learning Objectives:  Folding 3200 MB of DNA into nucleu...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 13: Louis Pasteur, Euglena, Spontaneous Generation
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Cell Theory, Structure, and Function Life Science, October 7, 2013 Euglena – flagellated protists; can be “animal” (heterotrophic) or “plant” (autotrophic – phagocytosis); make own food durin...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 12: Cephalopod Beak, Endoplasmic Reticulum, Nuclear Membrane
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Cell Structure and Function Life Science, October 9 , 2013 Architeuthis – (means “king squid”):  Giant squid – largest (up to 60 ft) invertebrate known; “kraken” – not seen alive unt...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 21: Mount Everest, Olympus Mons, Organic Synthesis
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Biogeochemical Cycles on Mars? October 30, 2013 Key Clues:  Active volcanism – provides reduced chemical species, which biota can use for organic synthesis; volcanic CO 2n...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 16: Oxygen Cycle, Nitrogen Fixation, Nitrogen Cycle
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Biogeochemical Cycles October 30, 2013 Oxygen Cycle: Oxygen is the 2 most abundant substance in our atmosphere. It is a powerful electron acceptor, as shown ...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 15: Lipid Bilayer, Tetrodotoxin, Resting Potential
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Bad Fish: Physiology Case Study November 14, 2013 Chemical Structure: 1. The tetrodotoxin molecule contains 4 different elements: C (carbon), N (nitrogen), O (oxygen), and...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 9: Hepatitis B Virus, Genital Wart, Herpes Labialis
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Infectious Agents and Cancer March 17, 2014 Koch’s Postulates:  Pathogen must be detected in diseased tissue  Must be isolated from host and grown in lab  Lab grown...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 8: Epistasis, Beta-Catenin, Mdm2
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Tumour Suppressor Genes March 24, 2014 One of first discovered tumour suppressors was responsible for retinoblastoma Ras-MAPK pathway – if a growth factor is present, this pathway i...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 4: Poisson Distribution, Radiobiology, Radiosensitizer
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Radiobiology Cell Survival Curves:  Describe relationship between radiation dose and proportion of surviving cells  Cell death may imply a loss of specific function in the case of differentiated cells ...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 3: Insertional Mutagenesis, Gene Duplication, Oncogene
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Oncogenes March 18, 2014 Normal cellular gees that can be converted into oncogenes are called proto-oncogenes. These are normal genes that make essential contributions to regulation of...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 2: Inverse-Square Law, Brachytherapy, Electronvolt
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Intro to Radiation Therapy and Treatment Planning March 19, 2014 Biological Basis:  Cells can be “killed” by ionizing radiation  Most important target = nuclear DNA ...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 7: Taxus Brevifolia, Debulking, Taxane
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Chemotherapeutic Agents March 17, 2014 Learning Objectives:  Complexity of cost-benefit analysis with human factors  Rationale for recommended treatments – with ovarian ca...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 1: Pap Test, Colorectal Cancer, Ethyl Acrylate
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Cancer Biology and Tumour Cell Defects March 3, 2014 Skin cancer has highest incidence rate, lung cancer has highest death rate. Breast cancer is most common in women. Prostate canc...

Integrated Science
ISCI 1A24
Carolyn Eyles
ISCI 1A24 Lecture Notes - Lecture 6: Redback Spider, Early Summer, Baboon
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Animal Behaviour March 31, 2014 Papio (genus) – baboons  In troops, tight-knit social groups with one alpha male  Can live up to 30, males reach maturity around 10, femal...

Integrated Science
ISCI 1A24
Carolyn Eyles

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