ISCI 1A24 Lecture Notes - Lecture 9: Hepatitis B Virus, Genital Wart, Herpes Labialis

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Pathogen must be detected in diseased tissue. Must be isolated from host and grown in lab. Lab grown pathogen must cause disease when administered to a healthy organism* Pathogen isolated from newly-infected host must be same as original pathogen* *difficult to prove in human population inferred logically. Burkitt"s lymphoma one of first instances of link between pathogens and cancer. Cultured tissue from growths found to contain epstein-barr virus. Plotted a number of cases as a function of location, took # of mosquitos per unit hectare as function of location plots could be almost overlain. Found that 90% of the world"s population is infected with this virus. People with inflammation in areas where malaria is common are more likely to develop cancer from epstein-barr virus. Over 100 different types from cold sores to genital warts. Hpv 16 and 18 are responsible for 70% of cervical cancers and 90% of genital warts, protected against by gardasil.

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