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Lecture 8

ISCI 3A12 Lecture Notes - Lecture 8: Warburg Effect, P53, Growth Factor

Integrated Science
Course Code
Carolyn Eyles

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Final Guest Lecture Dr. Evangelia Litsa Tsiani
Wine and Cancer
October 5, 2015
Activation of RAS and AKT leads to increased proliferation and cell survival.
#1 cause of death in Canada = cancer
45% of men and women will develop cancer in their lifetime.
Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancer cases. Majority of
cases present with advanced disease, and fewer than 15% live longer than 5 years following
Conventional treatments for lung cancer include surgery, radiotherapy, chemotherapy,
cancer growth inhibitors can be effective, but do not always work.
Wine consumed since 8000 years ago!
Resveratrol polyphenol in grape skin and seeds:
More in red wine than white
Known to have antioxidant properties
The “French Paradox
In France, although they have the same diet (more or less) as North America and
rest of Europe, but have much less cardiovascular disease
May be attributed to red wine consumption
Resveratrol found to have significant cardiovascular benefits in vivo and in vitro
Biological Effects of Resveratrol:
Antioxidant converts free radicals into harmless, unreactive compounds in body
Cardiovascular benefits
Resveratrol found to inhibit proliferation of cancer cells, and cancer treatments involving
resveratrol found to be more effective.
Use “nude” mice in animal models immunodeficient.
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