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Cardio KIN 2CC3 lecture Jan 23.pdf

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McMaster University
Krista Howarth

Cardiorespiratory KIN 2CC3 Lectures _____________________________________________▯ ▯ Overview: Oxidative Metabolism▯ - complete breakdown CHO, fats, AAs to Co2 and H20▯ - only system that uses all three fuels▯ - carbon molecules that are part of these fuels get completely broken down and we breathe that out.▯ - requires oxygen but provides sustained energy▯ ❖ could provide energy indefinitely as long as you’re not working too hard to produce ATP at that speed.▯ - ox metab is what keeps you alive, is being used at all times where demand is lower▯ - any exercise longer than 2 mins is primarily oxidative metabolism▯ - essential processes occur in mitochondrion▯ ❖ this is what causes a limitation on how fast we can get the fuels because of this extra step▯ - in general we get >35 units of ATP formed per unit of substrate▯ Mitochondria▯ - 2 membranes▯ - the outer membrane is permeable▯ - inner membrane is non-permeable▯ - in order to get things to move through the membrane we need transport systems or enzymes that can cause the movement of molecules through the membrane▯ ❖ oxygen can freely move through the membrane▯ - we need to have an electrical chemical gradient to produce ATP across the inner membrane▯ Transport System: ▯ - electron transport chain - acts as a shuttle system for molecules to move across the membrane▯ ❖ catalyzes reactions that move electrons and cause oxidation and reduction - eventually this will turn oxygen into water▯ ❖ this helps power the enzyme that can create the ATP▯ Oxidative Mtabolism: 3 Essential Steps▯ 1. Formation of Acetyl CoA - (CHO, fat. AA)▯ 2. Oxidation of Acetyl CoA - (Krebs Cycle/Citric Acid Cycle)▯ ❖ purpose of krebs cycle is to reduce coenzymes - FAD, FADH , N2DH▯ 3. Formation of ATP - (Electron Transport Chain)▯ ❖ coenzymes are oxidized▯ - cyclic process▯ ▯ Lipid▯ ▯ CHO▯ ▯ ▯ Protein▯▯ ‑▯▯ ‑▯▯ ▯ ‑▯ ▯ ▯ Acetyl CoA▯ ▯ OAA Citrate▯ ▯ ▯ Krebs Cycle▯ - the first product formed is citrate in the krebs cycle▯ - eventually forms oxaloacetate (OAA) - cyclic process▯ - substrates become products — eventually go back into substrates again▯ - we get rid of the carbons and reduce coenzymes▯ - FADH2 —> FAD▯ ▯ ▯ Electron Transport Chain▯ Cardiorespiratory KIN 2CC3 Lectures - oxygen gets reduced to water▯ - ADP + Pi —> ATP▯ ▯ Carbohydrate Oxidation▯ 1. Formation of acetyl CoA from Carbohydrate▯ ▯ Pyruvate + NAD —> Acetyl Co
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