KINESIOL 1AA3 Lecture Notes - Histopathology, Neoplasm, Adipose Tissue
Document Summary
A 52 year old sudanese woman presents with hot-flushes and night sweats. She has had no period for 14 months. Take a history from her, eliciting other symptoms relating to the climacteric: vaginal dryness, changes to the vulva, urinary symptoms i. e. frequency and nocturia, anxiety & depression (central symptoms) What treatment would you suggest to control this woman"s symptoms: replace oestrogen. If she still has a uterus: oestrogen is given in combination with progestogen to prevent unopposed oestrogen stimulation to the endometrium that could give rise to endometrial hyperplasia, atypia or neoplasia. Describe the various ways oestrogen/ progestogen replacement can be given: hrt may be given cyclically or continuously continuous more common. Progestogen-related: leg cramps, pmt-type symptoms ie irritability, bloating, headaches. If steroids are given sequentially, most women experience withdrawal menstrual" bleeding: 10% women will have excessive losses- up to 80mls, can be limited by giving drugs in continuous combined fashion. Is a major constraint in compliance to hrt.