KINESIOL 1YY3 Lecture Notes - Lecture 28: Zona Fasciculata, Releasing And Inhibiting Hormones, Adrenal Medulla

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Is broken down in the follicular cell releasing t3 and t4. T3 and t4 target all other cells. Iodine comes into cell (imp component of tsh) T3 and t4 are stored in the thyroglobulin. Thyroid hormones are bound to binding protein and interact with a nuclear receptor. Unlike most water soluble hormones which bind to membrane receptor. Releasing hormone from hypothalamus because of hypothermia or other stressors. Role of t3 and t4 is to inc metabolic rate. Immediately upon release into circulation it is bound. T3 has higher affinity for thyroid hormone receptor (which is a nuclear receptor not membrane receptor) Inc fat and glucose utilization for energy. Dec release of calcium to bring blood calcium level down. Humoral regulation change of conc of something in the blood is causing the release of a hormone. Embedded into posterior part of thyroid gland. Cells of medulla are larger and densely packed. Circulate within the plasma in a free form.

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