LIFESCI 2G03 Lecture Notes - Lecture 6: Trinucleotide Repeat Disorder, Dna Replication, Genetic Disorder
23 Mar 2018
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Document Summary
Everyone has cag repeats but people with huntington disease just have more. Complete penetrance: if you carry the allele, you will definitely show the symptoms. These alleles show complete penetrance - if you inherit the allele you will show symptoms. Incomplete penetrance: if you carry the allele, you may show the symptoms, you may not. This allele shows incomplete penetrance, if you inherit the allele you may show symptoms symptoms. Htt^36 , 36 cag repeats, may be affected but may not. Anticipation: a genetic disorder worsens with each generation. Htt^36 = huntington allele with 36 cag repeats in parent; when the allele is passed on to the offspring, there is a change in the number of repeats from 36 to 40. Now, the child that inherits the new htt40 allele will be affected. Anticipation is a result of a dna replication error during the production of gametes (usually in males).
