LIFESCI 2G03 Lecture Notes - Lecture 5: Restriction Enzyme, Striatum, Neurodegeneration
23 Mar 2018
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A hereditary form of chorea = the inability to control one"s muscles. Typically begins to appear in late 40"s and 50"s. Loss of fine motor control, slurring of speech. Loss of ability to walk, speech becomes incomprehensible. Patients can no longer swallow, memory becomes impaired. Within 15 years it can lead to death. As a young and young adult, no symptoms. The disease causing allele can be passed at any time. What is the prognosis? symptoms worsen no cure. If an individual carries the mutation, they will eventually show the symptoms. Found a polymorphic dna sequence tied to hd. The marker and the disease gene are so close together that that the marker and the diseased gene are passed together from one generation to the next. Disease allele mapped to the short arm of chromosome 4. Across the entire genome they"re look at a probe.
