Class Notes (838,371)
Canada (510,867)
Lecture

Fibromyalgia.pdf

2 Pages
51 Views
Unlock Document

Department
Life Sciences
Course
LIFESCI 3B03
Professor
Gautam Ullal
Semester
Winter

Description
Fibromyalgia February-05-13 2:56 PM Symptoms 1. Tenderness in at least 11 of 18 spots called "trigger points", accompanied by allodynia 2. Easily fatigues 3. Non-restorative sleep 4. No evidence of any physical/bodily related pathology 5. Most common in women F:M ratio = 9:1 6. Stressful childhood 7. Chronic disorder - Tenderness is reported in areas where muscles or ligaments attach to bones like the neck, shoulders, knees, thighs, lower back Neurobiological causes MRI scan - Shows reduced volume of grey matter in the PFC, amygdala and ACC - People on medication for fibromyalgia(NSAI) show an increase in grey matter compared to normal - The severity of pain in correlation to how long the patient had it for had no relationship - The medication had no effect on the pain, but their ability to cope with the pain was better than people not on medication PET scan - This PET scan was done in a patient in perimenopause. It showed hypoactivity in her insula compared to normal - We don't know if this was the cause Central sensitization - The pain matrix along with HPA axis both become sensitized due to an increase in glutamate and Substance-P - This increase in GLUT can be modulated by Gabapentin (GABA agonist) which will in turn decrease the [GLUT] - SNRIs are also effective in treatment (increase the amount of serotonin and norepinephrine at the synaptic cleft) Gate control theory of Pain - L-fiber
More Less

Related notes for LIFESCI 3B03

Log In


OR

Join OneClass

Access over 10 million pages of study
documents for 1.3 million courses.

Sign up

Join to view


OR

By registering, I agree to the Terms and Privacy Policies
Already have an account?
Just a few more details

So we can recommend you notes for your school.

Reset Password

Please enter below the email address you registered with and we will send you a link to reset your password.

Add your courses

Get notes from the top students in your class.


Submit