LIFESCI 3B03 Lecture Notes - Parietal Lobe, Fluoxetine, Fenfluramine
19 Feb 2013
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Document Summary
The likelyhood of suicide increases with age, peaking at adolescene and the second is at the 45 year old peak. Since the reproductive value declines with age, evolution may select suicide over survival due to lower progeny. Dukheim: breakdown of external social controls (something biochemical) which is an external cause. Frued: intrapsychic struggle, unconscious hostility towards the most loved object, "self" - Internal cause seems to be the forerunner to biological theories. The world is not ok, i am not ok, things are not going to be ok. An unseen pathway between the disease and genotype. It is used to compare complex behaviors to simple biological factors for the behavior (like epigenetics and gene expression) The endophenotype must be a marker of stable trait, be heritable and should correlate with the disease in the general population. Cognitive traits: poor decision making, poor executive functions. Neuroimaging: mri, fmri, pet (structural and functional defects in parts of the brain)
