LIFESCI 3A03 Lecture Notes - Lecture 3: Sh3 Domain, Philadelphia Chromosome, Thalidomide
20 Mar 2017
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The drug discovery process: we can break down the process by using the steps. It"s i(cid:373)porta(cid:374)t to k(cid:374)o(cid:449) the (cid:374)or(cid:373)al physiology to (cid:449)ork o(cid:374) the pathophysiology: most critical part selecting a target if (cid:449)e do(cid:374)"t (cid:272)hoose a proper target or hit the target effectively something can go wrong. Target selection = important: thalidomide disaster google. Thalidomide target identified 2010: target of thalidomide was identified the target did not belong to the mother but it belonged to fetus itself, crbn. It targeted e3 helps degrade proteins in normal limb development. Safety and toxicity tests: preclinical screening tests are administered now for every drug. Timeline of drug development: average time for drug development is 9 20 years. Selecting a target: bcr-abl: this is important not only to develop a successful drug but also to go pass the clinical trial process. Review: origin of cml: cml we have a large population of abnormal wbc compared to normal wbc and other cells.
