LIFESCI 2A03 Lecture 4: module 2 lecture 2
1 Oct 2018
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Somatic vs. germline types: somatic scs: produce body cells during organogenesis and tissue maintenance, germline scs (gscs): produce gametes (i. e. , eggs and sperm) Stepwise commitment of ascs: most tissues follow a stem cell progenitor cell differentiated cell hierarchy. Processes: symmetric cell division, asymmetric cell division, proginetor division, differentiation. Cells: stem cell, progenitor cell, differentiated or specialized cell. Controlled by: extrinsic factors, molecules secreted by other cells, physical contact with neighboring cells, intrinsic factors, differential segregation of: mrnas, cytosolic proteins, cell membrane proteins. Scs: specialized in producing more cells, self-renewal and differentiation potential. Progenitors: specialized in producing differentiated cells, they go through a limited number of cell division. Hematopoietic stem cells give rise to all blood cells. Intestinal epithelial organization: monolayer of cells, replaced every 2-3 days in mice, 3-5 in humans, scs give rise to progenitor cells that undergo differentiation giving rise to different types of differentiated cells.
