LIFESCI 2L03 Lecture Notes - Lecture 4: Beta-Galactosidase, Proteopathy, Hydrophile
14 Jul 2018
School
Department
Course
Professor
Document Summary
Cellular theories of aging propose that human aging is the result of cellular aging, whereby an increasing proportion of cells reach senescence. Cell death is normal, we turnover our cells every day, (cells die and are replaced by healthy cells) Instead, we define cellular aging by cell divisions. Older cells are the result of more cell divisions. Cellular senescence is the loss of the ability of cells to divide as cells age (i. e. after they have divided many times) Cells grow larger, flatten shape and expressed senescence-associated beta galactosidase (sabg, blue areas) As the body ages, cells contain increasing number of toxic protein aggregates. (links to. Polar (hydrophilic) side chains, interact more strongly with water. Non polar (hydrophobic) side chains, cluster away from water. Protein structures are stabilized by non-covalent interactions and disulphide bonds between two cysteine residues. The non covalent interactions: ionic interactions, hydrogen bonds, hydrophobic interactions and weak van der waals interactions.
