LIFESCI 2N03 Lecture Notes - Lecture 12: Red Blood Cell, Glycogenolysis, Fluid Balance
7 views23 pages
8 Feb 2016
School
Department
Course
Professor
!"#
#
$%#&'"(#)#*+,-.#'+/01/12.#320#$134#%514.546#
7898#:1.51;402<#&"=>#
#
LECTURE'
BIOENERGETICS'
WHAT'IS'METABOLISM?#
%+,#23#-??#5@4,15-?#04-5/12.6#/@-/#255+0#1.#/@4#A2BC#
#
Anabolic'reactions'
• %C./@4616#23#,2?45+?46#
#
Catabolic'reactions'
• D04-EB2F.#23#,2?45+?46#
'
Bioenergetics#
• G2.;40/1.H#322B6/+336#I3-/6<#J02/41.6<#5-0A2@CB0-/46K#1./2#4.40HC#
#
#
THE'EUKARYOTIC'CELL'
#
#
L@4#,1/25@2.B012.#
M 91/25@2.B012.#16#/@4#4.40HC#3-5/20C#
M 9-E4#54??#N,2.4CO#@404##
#
G4??+?-0#,4,A0-.4#
M 9-P20#62+054#23#54??+?-0#4?45/0151/C#-.B#1./0-M54??+?-0##
%1H.-?1.H8##
M Q44J1.H#/@4#54??#-?1;4#-.B#-??2F1.H#/@4#54??#/2#046J2.B#/2#4R/40.-?##
S.;102.,4./8##
M G4??+?-0#4?45/0151/CM#-5/12.#J2/4./1-?6##
M T./0-#54??+?-0#61H.-?1.H#16#/@4#302,#/@4#2+/61B4#/2#/@4#1.61B4#
M LCJ4#&#B1-A4/46#,4??1/+6M#1.6+?1.#16#01.H1.H#/@4#B220A4??#A+/#/@4#54??#5-.U/#A01.H#1/#1.#A45-+64#
/@4#,45@-.16,#16#A02E4.#1.61B4#/@4#54??8##
#
#
'+5?4+6#
M 7.-#16#/@4#.-/+04U6#J?-.#/@-/#H2;40.6#/@4#54??6##
M 7.-#16#E4J/#1.#5?264B#-.B#B16/1.5/#52,J-0/,4./##
!=#
#
$%#&'"(#)#*+,-.#'+/01/12.#320#$134#%514.546#
7898#:1.51;402<#&"=>#
#
PROTEIN'SYNTHESIS'
'
=8 7'V#52./-1.6#1.320,-/12.#/2#J02B+54#J02/41.68##
&8 L0-.6501J/12.#J02B+546#,W'V8#
(8 ,W'V#?4-;46#.+5?4+6#-.B#A1.B6#/2#01A262,48#
>8 V,1.2#-51B6#-04#5-0014B#/2#/@4#01A262,4#AC#/W'V8#
X8 T.#/0-.6?-/12.<#,W'V#16#+64B#/2#B4/40,1.4#/@4#-00-.H4,4./#23#-,1.2#-51B6#1.#/@4#J2?CJ4J/1B4#
5@-1.8#
M Y@-/#F4#B2#-.B#F@-/#F4#4-/#-3345/6#/@4#0-/4##
M Z+0#A2BC#52.6/-./?C#,-E46#.4F#J02/41.6#A+/#1/U6#-#A-?-.54##
M '+5?4+6#16#/@4#J?-54#F@404#/@4#J?-.6#-04#-/##
M V0H1.1.4#-.B#-6J-0/15#-51B#-04#-,1.2#-51B68#V,1.2#-51B6#-04#+64B#/2#504-/4#3+.5/12.-?#J02/41.6#
F@15@#5-00C#2+/#1/6#1./4.B4B#J+0J2648#G2./0-5/1?4#J02/41.6#J02B+51.H#32054#-.B#B16J?-51.H#2+0#
A2.468##
M %2,4#54??6#,166#62,4#-,1.2#-51B6#-.B#5-.#/@4.#A452,4#1./2#5-.5402+6#54??68#G-.5402+6#54??6#
-04#H02F1.H#-.B#J02?1340-/1.H#F1/@2+/#6/2JJ1.H#-.B#/@4C#6/-0/#/2#6@+/#B2F.#62,4#23#2+0#
20H-.68##
!&#
#
$%#&'"(#)#*+,-.#'+/01/12.#320#$134#%514.546#
7898#:1.51;402<#&"=>#
#
'WHAT'ARE'ENZYMES?'
#
G-/-?C6/6#/@-/#04H+?-/4#/@4#6J44B#23#04-5/12.6#
• $2F40#/@4#4.40HC#23#-5/1;-/12.#
'
Factors'that'regulate'enzyme'activity#
– L4,J40-/+04#
– J*#
#
What'role'do'enzymes'play'in'metabolism?'
S.[C,46#-04#J02/41.6#/@-/#A01.H#/2H4/@40#4.[C,4#6+A6/0-/4##
G2,J?4R#-.B#4.H-H46#1.#62,4#/CJ4#23#5@4,15-?#04-5/12.#/@-/#6J44B6#+J##
L@4#6J44B#23#04-5/12.68##
%+50264#
M Y@4.#/-A?4#6+H-0#5@4,15-??C#A1.B6#/2#540/-1.#-,1.2#-51B6#1.#/@4#J02/41.#/@4#A1.B1.H#F1??#
B46/-A1?1[4#A2.B6#@2?B1.H#/@4,#/2H4/@40#-.B#/@4C#3-??#-J-0/8##
M L@16#5@4,15-?#6/4J#16#01H@/#13#C2+#31.16@4B#-#>X#,1.+/4#0+.#I5-0A6#A04-E#B2F.K#A+/#5-.#-?62#A4#
A-B#320#-#/CJ4#&#B1-A4/46#,4??1/+6#J4062.8##
T3#C2+#F-./#/2#43345/#/@4#5@4,15-?#04-5/12.#!#H2#-3/40#/@4#4.[C,46##
T.504-64#/@4#4.[C,4#-5/1;1/C!#1.504-64#/@4#0-/4#23#04-5/12.#-.B#;154#;406-#
#
Effect'of'temperature'
#
M ZJ/1,-?#?4;4?#320#/4,J40-/+04#16#A46/#302,#(\M>"#B4H0446#
M %E1.#/4,J40-/+04#H246#+J#F1/@#4R405164!#A2BC#16#/0C1.H#/2#522?#B2F.#AC#04?4-61.H#@4-/#
M L2#522?#23#,+65?4#/166+4<#F4#@4-/#+J#A?22B8#9+65?4#/166+4#/4,J#04,-1.6#52.6/-./8##
#
#
#
#
#
#
#
Effect'of'pH'
M L22#@1H@#20#/22#?2F#J*#5-.#B4.-/+04#J02/41.6#/@4043204#?2F401.H#/@4#4.[C,4#-5/1;1/C8##
M $-5/15#-51B#J02B+54B#F@4.#/22#,+5@#4R405164!#A-B#
#
#
#