LIFESCI 3AA3 Lecture Notes - Lecture 14: Glioblastoma Multiforme, Parietal Lobe, Frontal Lobe
9 Dec 2018
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Document Summary
Symptoms: seizures, nausea, headaches, vomiting, memory loss, paralysis on one side of body: often asymptomatic until large tumour. Most common malignant type of brain tumour. 4 diagnoses per 100,000 people per year. More prevalent for those of european descent and males. Average age at diagnosis is 55 years old. Tumour develops in glial cells of subcortical white matter: necrosis (death of tissue) and vascularization at tumours, as tumour grows, complications due to increased pressure and interference w/ brain function. Primary glioblastoma originated there - more severe, develops rapidly, vascularization. Secondary glioblastoma arise from existing low-grade gliomas, slower growth, lower grade. Survival of malignant tumour w/o treatment is 3-4 months. Develop in critical brain regions: frontal lobe cognitive processing, language, memory, temporal lobe hearing, language and speech; could seem like a stroke, parietal lobe sensory info (may have weird smell) Neurological exam tests vision, hearing, balance, coordination, reflexes and memory. Biopsy can be dangerous / cause damage.
