MEDRADSC 1B03 Lecture Notes - Lecture 2: Hepatectomy, Metaplasia, Dysplasia
12 Feb 2018
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Document Summary
Cellular adaptation: apoptosis: predetermined cell death, five ways cells adapt to change: atrophy, hypertrophy, hyperplasia, metaplasia, dysplasia. Smokers: delicate ciliated cells die, so they are replaced with more resilient cells to protect structures. That"s why smokers have a hard time eliminating things in their lungs, no cilia: since cells are changing, there is a chance that one of those cells can become uncontrolled, leading to cancer. Dysplasia: tissue in which cells vary in size and shape. In response to chronic irritation/infection or may be a precancerous change ** 80% of cases does not develop into cancer: ex. respiratory tract of smokers and cervix (base of the pap) cervical carcinoma connection, precancerous conditions of the cervix occur in an area called the transformation zone. This is where one type of lining (glandular, columnar cells) is constantly being changed into another type of lining (squamous cells).
