MEDRADSC 2T03 Lecture Notes - Lecture 6: Hematopathology, Notch 2, National Cancer Institute
27 Jun 2016
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Document Summary
Primary splenic lymphomas (sls) represent a very small percentage of malignancies. 36. They most commonly present as a form of non-hodgkin lymphoma (nhl) and develop in the b lymphocytes. Sls account for less than 1% of lymphomas. Incidence is reported as 0. 13 per 100,000 persons. More common in the elderly (65-84 years of age). Median age of occurrence is 68 years. Higher incidence rates in caucasians and non-hispanic males. More common in the united states, canada, and europe. Note: because sls are so rare, it is difficult to characterize the risk factors associated with them. Below is a list of possible and known factors that contribute to the malignancy: Note: molecular abnormalities are present in many sls. Complete or partial trisomy of chromosome 3q. Immunophenotypic expression of cd19, cd20, cd22, cd79a, cd79b2, fmc7, igm and igd have also been noted. Immunophenotyping = the study of proteins expressed by cells. List of risk factors for nhls (not necessarily specific to sls)7.
