MEDRADSC 2X03 Lecture Notes - Lecture 3: Hydroxy Group, Antibody, Photon

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Produced as a by-product of x-ray and electron beams in linear accelerators operating at 10 mev+ Experience multiple scatterings within room (walls, floor, ceiling) In tissue, usually proton of hydrogen nucleus set in motion. Some transferred energy used in overcoming binding forces (final total ek < initial ek) They interact with oxygen and carbon and produce something new. Alpha particles contain 2 protons and 2 neutrons. Radiation-induced injury to an organism always begins with chemical changes at the atomic or molecular level. Ionizations (broken chemical bonds) changed molecular structure changed chemical or functional behaviour. Collisional interaction of electrostatic fields causes ionization (2 molecules interact) High energy charged particles are directly ionizing: high energy electrons, protons, alpha particles. It will still reproduce when it is damaged and create another damaged strand. Photo(cid:374) (cid:272)a(cid:374) k(cid:374)o(cid:272)k out a (cid:272)ell"s dna (cid:271)ases (cid:894)happe(cid:374)s with large particles or radiation that has more energy), larger particles, higher energy.

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