MEDRADSC 2X03 Lecture 8: Module 3 Unit 1 and 2

• School: McMaster University
• Department: Medical Radiation Sciences
• Course: MEDRADSC 2X03
• Professor: Sandra Charbonneau

Document Summary

Always leads to cell death: apoptotic, mitotic death: Associated mainly with asymmetrical exchange-type aberrations (render the cell unable to reproduce) (e. g. rings, dicentrics, anaphase bridge) Typically the mode of radiation-i(cid:374)duced death for vim cells (cid:894)casarett(cid:859)s type 1) Vim cells- most sensitive cells we have (rbc, epithelial cells): we will see the. Evidence points to damage of chromosomal dna as basis of radiation-induced lethality damage quicker because they divide quickly. May or may not be reversible or reparable. Can be demonstrated after a single irradiation of cells. Normally reversible, reparable, as long as repair can occur prior to additional damage sustained (before another hit) Increased cell survival for given total dose when dose is split into fractions administered over multiple intervals of time (break up the dose so that we see the cell line staying closer to unity) Cells receive increment (smaller) dose, than have time to repair before next dose.